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GW501516isshowntobethemostpotentandselectivePPARαagonistsknownwithanEC50of1.1nMagainstPPARαand1000-foldselectivityovertheotherhumansubtypes,PPARαand-γ.GW501516exerChemicalbooktsanti-inflammatoryeffectsinmouseculturedproximaltubular(mProx)cells.GW501516inhibitspalmitate-andTNFα-inducedincreasesinMCP-1mRNAexpressioninadose-dependentmanner.
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MOSCOW
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