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Myocardial infarction is one of the most deadly cardiovascular diseases. Myocardial infarction is caused by coronary artery stenosis or spasm, resulting in acute or persistent ischemia and hypoxia of the heart muscle, and cardiac cell death. Several pro-inflammatory cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor-chemicalbook α(TNF-α) are involved in myocardial remodeling 3. SR9011 is a REV-ERBα/β agonist, a member of the nuclear receptor family, which has been found to regulate the metabolism of biological tissues.
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